Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase.

Selenium and selenium-dependent antioxidants in chronic kidney disease.

Oxidative stress plays a key role in numerous disease processes including chronic kidney disease (CKD). In general, oxygen metabolism leads to the formation of reactive oxygen species (ROS) dangerous to cells. Although enzymes and low-molecular-weight antioxidants protect against ROS, chronic imbalances of formation and elimination can eventually overwhelm endogenous defenses leading to deleter...

Effect of Selenium Supplementation on Glutathione Peroxidase Enzyme Activity in Patients With Chronic Kidney Disease: A Randomized Clinical Trial

BACKGROUND Plasma selenium (Se) concentration and glutathione peroxidase (GSH-Pxs) enzyme activity of the patients with chronic kidney disease (CKD) are usually lower than healthy individuals; however, the effect of Se supplementation on the GSH-Pxs activity in those patients remains unclear. OBJECTIVES This study aimed to assess the effect of Se supplementation on plasma Se concentration and...

Selenium (Se), Blood Glutathione Peroxidases and DNA Damage in Chronic Kidney Disease Patients on Hemodialysis and After Kidney Transplantation - The Effect of Se Supplementation

Selenium plasma levels in hemodialysis patients: comparison between North and Southeast of Brazil.

INTRODUCTION Patients with chronic kidney disease present selenium (Se) plasma deficiency which is an essential trace element with important biological functions and, the best known biological role is attributed to its presence in the antioxidant enzyme, glutathione peroxidase (GPx). The Se content of foods depends on soil and some authors have suggested that Amazon soil (North Brazilian region...

Does Vitamin E Influence Oxidative Stress And Renal Anaemia In Haemodialysed Patients?

There is increasing evidence that oxygen radicals are involved in the progression of renal damage and of uraemic symptoms. Haemodialysis (HD) is known to be one major cause of oxidative stress. Renal anaemia is one of the main complications seen in HD patients and resulting from many pathogenic factors. In this study we aimed to evaluate the role of oxidative stress as a contributing factor in ...